NFL Week 2: Odds, Lines, Margins and Best Bets | NFL and NCAA Betting Choices

• After Week 1 that included five wins in the last two minutes of regulation or overtime, week two kicks off Thursday with the AFC game between Justin Herbert Chargers and Patrick Mahomes Chiefs and concludes with a double-header Monday night with the Titans at Buffalo before the Vikings visit Philadelphia.

• The Mahomes threw five touchdowns for the sixth time in his career as the Chiefs broke up Arizona, 44-21. Herbert threw with three, OLB new Khalil Mack scored three sacks and forced a foul against his former team, the Raiders, in the Chargers’ 24-19 win.

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Here are the early week two lines, courtesy of BetMGM. Our best early looks are coming soon.

Thursday 15 September

Los Angeles Chargers @ Kansas City Chiefs

Spread the total money line
chargers +3 (-105) O 54 (-110) +145
heads -3 (-105) S 54 (-110 -175

Sunday 18 September

Miami Dolphin @ Baltimore Ravens

Spread the total money line
dolphins +3.5 (-115) O 45.5 (-110) +150
crows -3.5 (-105) U 45.5 (-110) -185

New York Jets @ Cleveland Browns

Spread the total money line
Planes +6 (-110) O 42.5 (-110) +220
Brown -6 (-110) S 42.5 (-110) -275

Washington leaders @ Detroit Lions

Spread the total money line
leaders +1.5 (-105) O 46.5 (-110) +110
black -1.5 (-115) U 46.5 (-110) -135

Indianapolis Colts @ Jacksonville Jaguars

Spread the total money line
ponies -4.5 (-110) O 45.5 (-115) -200
Jaguar +4.5 (-110) U 45.5 (-105) +170

Carolina Panthers @ New York Giants

Spread the total money line
leopards +2.5 (-110) O 43.5 (-110) +110
giants -2.5 (-110) U 43.5 (-110) -135

Atlanta Falcons @ Los Angeles rams

Spread the total money line
hawks +10.5 (-115) O47.5(-115) +450
rams -10.5 (-105) U47.5 (-115) -650

Seattle Seahawks @ San Francisco 49ers

Spread the total money line
Seahawks +9.5 (-110) O42.5 (-105) +340
49ers -9.5 (-110) U42.5 (-115) -450

Houston Texas @ Denver Broncos

Spread the total money line
Texas +10 (-110) O43.5 (-115) +340
Bronco -10 (-110) U43.5 (-105) -450

New England Patriots @ Pittsburgh Steelers

Spread the total money line
patriots To be announced To be announced To be announced
Steelers To be announced To be announced To be announced

Arizona Cardinals @ Las Vegas Raiders

Spread the total money line
basics +3.5 (-110) O51.5 (-110) +155
Raiders -3.5 (-110) U51.5 (-110) -165

Chicago Bears @ Green Bay Packers

Spread the total money line
bear +9.5 (-110) O43.5 (-110) +325
Packers -9.5 (-110) U43.5 (-110) -400

Monday 19 September

Tennessee Titans @ buffalo bills

Spread the total money line
titans +9.5 (-105) O49.5 (-115) +325
Invoices -9.5 (-115) U49.5 (-105) -400

Minnesota Vikings @ Philadelphia Eagles

Spread the total money line
titans +3 (-120) O49.5 (-110) +120
Invoices -3 (+100) U49.5 (-110) -145